A waitress and a housewife try to get away from their boyfriend and husband for a weekend but instead end up on a crosscountry crime spree through the South.

Single dad and struggling animal handler Eddie works with lots of creatures, but at home, he has a strict No Pets Allowed policy. He won't let his son Billy keep the adorable stray dog Beethoven and his family of puppies. Beethoven crashes into Hollywood and into Eddie's heart as well.